Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-5 (of 5 Records) |
Query Trace: Yacisin K[original query] |
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Outbreak of non-tuberculous mycobacteria skin or soft tissue infections associated with handling fish - New York City, 2013-2014
Yacisin K , Hsieh JL , Weiss D , Ackelsberg J , Lee E , Jones L , Leung YL , Li L , Yung J , Slavinski S , Hanson H , Ridpath A , Kornblum J , Lin Y , Robbe-Austerman S , Rakeman J , Siemetzki-Kapoor U , Stuber T , Greene SK . Epidemiol Infect 2017 145 (11) 1-11 Mycobacterium marinum, a bacterium found in freshwater and saltwater, can infect persons with direct exposure to fish or aquariums. During December 2013, the New York City Department of Health and Mental Hygiene learned of four suspected or confirmed M. marinum skin or soft tissue infections (SSTIs) among persons who purchased whole fish from Chinese markets. Ninety-eight case-patients with non-tuberculous mycobacteria (NTM) SSTIs were identified with onset June 2013-March 2014. Of these, 77 (79%) were female. The median age was 62 years (range 30-91). Whole genome sequencing of clinical isolates revealed two main clusters and marked genetic diversity. Environmental samples from distributors yielded NTM though not M. marinum. We compared 56 case-patients with 185 control subjects who shopped in Chinese markets, frequency-matched by age group and sex. Risk factors for infection included skin injury to the finger or hand (odds ratio [OR]: 15.5; 95% confidence interval [CI]: 6.9-37.3), hand injury while preparing fish or seafood (OR 8.3; 95% CI 3.8-19.1), and purchasing tilapia (OR 3.6; 95% CI 1.1-13.9) or whiting (OR 2.7; 95% CI 1.1-6.6). A definitive environmental outbreak source was not identified. |
Clinical and pathological evaluation of Mycobacterium marinum group skin infections associated with fish markets in New York City
Sia TY , Taimur S , Blau DM , Lambe J , Ackelsberg J , Yacisin K , Bhatnagar J , Ritter J , Shieh WJ , Muehlenbachs A , Shulman K , Fong D , Kung E , Zaki SR . Clin Infect Dis 2015 62 (5) 590-5 BACKGROUND: From December 2013 through May 2014, physicians, dermatopathologists, and public health authorities collaborated to characterize an outbreak of Mycobacterium marinum and other nontuberculous mycobacterial skin and soft tissue infections (SSTIs) associated with handling fish in New York City's Chinatown. Clinicopathologic and laboratory investigations were performed on a series of patients. METHODS: Medical records were reviewed for 29 patients. Culture results were available for 27 patients and 24 biopsy specimens were evaluated by histopathology, immunohistochemistry (IHC) staining for acid-fast bacilli (AFB), and mycobacterial polymerase chain reaction (PCR) assays. RESULTS: All patients received antibiotics. The most commonly prescribed antibiotic regimen was clarithromycin and ethambutol. Of the 29 patients in this case series, 16 (55%) received surgical treatment involving incision and drainage, mass excision, and synovectomy. Of these, 7 (44%) had deep tissue involvement. All patients showed improvement. For those with culture results, 11 of 27 (41%) were positive for M. marinum; the remainder showed no growth. Poorly formed granulomas (96%), neutrophils (75%), and necrosis (79%) were found in 24 biopsies. Of 15 cases that were culture-negative and analyzed by other methods, 9 were PCR positive for M. marinum group species, 8 were IHC positive, and 3 were positive by AFB stains. CONCLUSIONS: A multidisciplinary approach was used to identify cases in an outbreak of M. marinum infections. The use of histopathology, culture, and IHC plus PCR from full thickness skin biopsy can lead to improved diagnosis of M. marinum SSTIs compared to relying solely on mycobacterial culture, the current gold standard. |
Ebola virus disease in a humanitarian aid worker - New York City, October 2014
Yacisin K , Balter S , Fine A , Weiss D , Ackelsberg J , Prezant D , Wilson R , Starr D , Rakeman J , Raphael M , Quinn C , Toprani A , Clark N , Link N , Daskalakis D , Maybank A , Layton M , Varma JK . MMWR Morb Mortal Wkly Rep 2015 64 (12) 321-3 In late October 2014, Ebola virus disease (Ebola) was diagnosed in a humanitarian aid worker who recently returned from West Africa to New York City (NYC). The NYC Department of Health and Mental Hygiene (DOHMH) actively monitored three close contacts of the patient and 114 health care personnel. No secondary cases of Ebola were detected. In collaboration with local and state partners, DOHMH had developed protocols to respond to such an event beginning in July 2014. These protocols included safely transporting a person at the first report of symptoms to a local hospital prepared to treat a patient with Ebola, laboratory testing for Ebola, and monitoring of contacts. In response to this single case of Ebola, initial health care worker active monitoring protocols needed modification to improve clarity about what types of exposure should be monitored. The response costs were high in both human resources and money: DOHMH alone spent $4.3 million. However, preparedness activities that include planning and practice in effectively monitoring the health of workers involved in Ebola patient care can help prevent transmission of Ebola. |
Surveillance and preparedness for Ebola virus disease - New York City, 2014
Benowitz I , Ackelsberg J , Balter SE , Baumgartner JC , Dentinger C , Fine AD , Harper SA , Jones LE , Laraque F , Lee EH , Merizalde G , Quinn C , Slavinski S , Winters AI , Weiss D , Yacisin KA , Varma JK , Layton MC . MMWR Morb Mortal Wkly Rep 2014 63 (41) 934-6 In July 2014, as the Ebola virus disease (Ebola) epidemic expanded in Guinea, Liberia, and Sierra Leone, an air traveler brought Ebola to Nigeria and two American health care workers in West Africa were diagnosed with Ebola and later medically evacuated to a U.S. hospital. New York City (NYC) is a frequent port of entry for travelers from West Africa, a home to communities of West African immigrants who travel back to their home countries, and a home to health care workers who travel to West Africa to treat Ebola patients. Ongoing transmission of Ebolavirus in West Africa could result in an infected person arriving in NYC. The announcement on September 30 of an Ebola case diagnosed in Texas in a person who had recently arrived from an Ebola-affected country further reinforced the need in NYC for local preparedness for Ebola. |
Notes from the field: rapidly growing nontuberculous mycobacterium wound infections among medical tourists undergoing cosmetic surgeries in the Dominican Republic - multiple states, March 2013-February 2014
Schnabel D , Gaines J , Nguyen DB , Esposito DH , Ridpath A , Yacisin K , Poy JA , Mullins J , Burns R , Lijewski V , McElroy NP , Ahmad N , Harrison C , Parinelli EJ , Beaudoin AL , Posivak-Khouly L , Pritchard S , Jensen BJ , Toney NC , Moulton-Meissner HA , Nyangoma EN , Barry AM , Feldman KA , Blythe D , Perz JF , Morgan OW , Kozarsky P , Brunette GW , Sotir M . MMWR Morb Mortal Wkly Rep 2014 63 (9) 201-2 In August 2013, the Maryland Department of Health and Mental Hygiene (MDHMH) was notified of two persons with rapidly growing nontuberculous mycobacterial (RG-NTM) surgical-site infections. Both patients had undergone surgical procedures as medical tourists at the same private surgical clinic (clinic A) in the Dominican Republic the previous month. Within 7 days of returning to the United States, both sought care for symptoms that included surgical wound abscesses, clear fluid drainage, pain, and fever. Initial antibiotic therapy was ineffective. Material collected from both patients' wounds grew Mycobacterium abscessus exhibiting a high degree of antibiotic resistance characteristic of this organism. |
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